{"id":7569,"date":"2019-11-08T15:07:33","date_gmt":"2019-11-08T14:07:33","guid":{"rendered":"https:\/\/www.l3s.de\/?page_id=7569"},"modified":"2023-01-11T17:15:54","modified_gmt":"2023-01-11T16:15:54","slug":"big-data-against-the-norovirus","status":"publish","type":"page","link":"https:\/\/www.l3s.de\/de\/magazine\/binaire-articles\/big-data-against-the-norovirus\/","title":{"rendered":"Big Data gegen das Norovirus"},"content":{"rendered":"
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Foto: Adobe Stock<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Ausgabe: 02\/2019<\/p>\n <\/div>\n <\/div>\n

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Big Data in der Medizin<\/span><\/a>\n <\/span>\n <\/div>\n <\/div>\n
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Big Data gegen das Norovirus<\/h1>\n <\/div>\n <\/div>\n
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Pl\u00f6tzliche \u00dcbelkeit, heftiges Erbrechen, Durchfall: f\u00fcr einen\u00a0Gro\u00dfteil der Magen-Darm-Infekte (Gastroenteritiden)\u00a0sind Noroviren verantwortlich.\u00a0Sie sind hochinfekti\u00f6s und k\u00f6nnen\u00a0akute Gastroenteritis-Ausbr\u00fcche in Gemeinschaftseinrichtungen, Krankenh\u00e4usern, Altenheimen oder auch auf Kreuzfahrtschiffen ausl\u00f6sen.\u00a0 Besonders gef\u00e4hrlich sind Noroviren f\u00fcr\u00a0immungeschw\u00e4chte Patienten, beispielsweise nach einer Organtransplantation, da sie chronische Infektionen etablieren und Komplikationen ausl\u00f6sen k\u00f6nnen.<\/p>\n

Bisher gibt es weder einen Impfstoff\u00a0noch eine spezifische Therapie zur Vorbeugung oder Behandlung von Norovirus-Infektionen. Auch ist nicht bekannt, was die individuellen Unterschiede in der Anf\u00e4lligkeit und im Infektionsverlauf ausmacht. Am\u00a0Zentrum f\u00fcr Individualisierte Infektionsmedizin,\u00a0das zurzeit in Hannover entsteht, werden im Forschungsprojekt\u00a0PRESENt\u00a0Wissenschaftler des\u00a0TWINCORE, der\u00a0Medizinischen Hochschule Hannover, des\u00a0Helmholtz-Zentrums f\u00fcr Infektionsforschung\u00a0und des\u00a0L3S\u00a0gemeinsam nach den Ursachen dieser Varianzen suchen.\u00a0In klinischen Studien werden die\u00a0PRESENt-Forscher \u00fcber 5000 Patientendatens\u00e4tze auswerten und mittels\u00a0Big-Data-Analysemethoden\u00a0kritische Faktoren f\u00fcr die Entwicklung von Komplikationen durch eine Norovirus-Infektion aufdecken. Das Ziel ist,\u00a0die\u00a0Anf\u00e4lligkeit\u00a0jedes einzelnen Patienten f\u00fcr komplizierte und schwere Noroviruserkrankungen pr\u00e4zise und schnell\u00a0vorherzusagen. Die Wissenschaftler setzen daf\u00fcr klinische Daten und individuelle Parameter wie Geschlecht, Alter und Vorerkrankungen in Relation zueinander und berechnen Muster f\u00fcr den Infektionsverlauf.\u00a0Im n\u00e4chsten Schritt wird das Konsortium die Wirksamkeit von Desinfektionsmitteln gegen Patienten-isolierte Norovirusproben testen. Zuletzt werten die Forscher Mikrobiom-Daten dahingehend aus, ob eine\u00a0Probiotikatherapie\u00a0schwere Norovirusinfektionen verhindern und chronische Infektionen heilen kann.\u00a0Somit soll\u00a0PRESENt\u00a0nicht nur individuelle Unterschiede des Norovirusinfektionsverlaufs aufdecken, sondern vor allem eine\u00a0personalisierte Prognose, Pr\u00e4vention und Behandlung von schweren Norovirusverl\u00e4ufen\u00a0erm\u00f6glichen.<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Kontakt<\/h6>\n <\/div>\n <\/div>\n
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Dr. Megha Khosla<\/h6>\n <\/div>\n <\/div>\n
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khosla@l3s.de<\/span><\/a>\n <\/span>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n
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Megha Kosla ist wissenschaftliche Mitarbeiterin am L3S. Sie erforscht Machine-Learning-Verfahren zur Analyse komplexer Daten wie den Sozialen Netzwerken, Web-Graphen und biomedizinischen Daten.<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

Foto: Adobe Stock Issue: 02\/2019 Big Data in der Medizin Big Data against the Norovirus Sudden nausea, violent vomiting, diarrhoea: Noroviruses are responsible for the majority of gastrointestinal infections (gastroenteritis). They are highly infectious and can cause acute gastroenteritis outbreaks in community facilities, hospitals, retirement homes or on cruise ships. Noroviruses are particularly dangerous for immunocompromised patients, for example […]<\/p>","protected":false},"author":7,"featured_media":7570,"parent":2750,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/full-width-page.php","meta":{"_acf_changed":false,"footnotes":""},"categories":[],"tags":[28,87],"class_list":["post-7569","page","type-page","status-publish","has-post-thumbnail","hentry","tag-binaire","tag-binaire-2019-02"],"acf":[],"aioseo_notices":[],"publishpress_future_action":{"enabled":false,"date":"2026-05-05 03:49:39","action":"category","newStatus":"draft","terms":[75],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.l3s.de\/de\/wp-json\/wp\/v2\/pages\/7569","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.l3s.de\/de\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.l3s.de\/de\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.l3s.de\/de\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.l3s.de\/de\/wp-json\/wp\/v2\/comments?post=7569"}],"version-history":[{"count":0,"href":"https:\/\/www.l3s.de\/de\/wp-json\/wp\/v2\/pages\/7569\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.l3s.de\/de\/wp-json\/wp\/v2\/pages\/2750"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.l3s.de\/de\/wp-json\/wp\/v2\/media\/7570"}],"wp:attachment":[{"href":"https:\/\/www.l3s.de\/de\/wp-json\/wp\/v2\/media?parent=7569"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.l3s.de\/de\/wp-json\/wp\/v2\/categories?post=7569"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.l3s.de\/de\/wp-json\/wp\/v2\/tags?post=7569"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}